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Article

A Nucleolar Stress–Specific p53–miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network

1 Jul 2018

Abstract excerpt

BACKGROUND: Activation of intrinsic p53 tumor-suppressor (TS) pathways is an important principle underlying cancer chemotherapy. It is necessary to elucidate the precise regulatory mechanisms of these networks to create new treatment strategies. METHODS: Comprehensive analyses were carried out by microarray. Expression of miR-101 was analyzed by clinical samples of lung adenocarcinomas. FINDINGS: We discovered a...

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PMID: 30049386
DOI: 10.1016/j.ebiom.2018.06.031

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