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Article

Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance.

Nucleic acids research - 1 Jan 2010

Szczesny Roman J, Borowski Lukasz S, Brzezniak Lien K, Dmochowska Aleksandra, Gewartowski Kamil, Bartnik Ewa, Stepien Piotr P

Abstract excerpt

The mechanism of human mitochondrial RNA turnover and surveillance is still a matter of debate. We have obtained a cellular model for studying the role of hSuv3p helicase in human mitochondria. Expression of a dominant-negative mutant of the hSUV3 gene which encodes a protein with no ATPase or helicase activity results in perturbations of mtRNA metabolism and enables to study the processing and degradation...

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Identifiers

PMID: 19864255
DOI: 10.1093/nar/gkp903
PMCID: PMC2800237

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