Article
Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance.
Nucleic acids research - 1 Jan 2010
Szczesny Roman J, Borowski Lukasz S, Brzezniak Lien K, Dmochowska Aleksandra, Gewartowski Kamil, Bartnik Ewa, Stepien Piotr P
Abstract excerpt
The mechanism of human mitochondrial RNA turnover and surveillance is still a matter of debate. We have obtained a cellular model for studying the role of hSuv3p helicase in human mitochondria. Expression of a dominant-negative mutant of the hSUV3 gene which encodes a protein with no ATPase or he...
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