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Article

Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate.

JCI insight - 26 Jul 2018

Mestre-Francés Nadine, Serratrice Nicolas, Gennetier Aurélie, Devau Gina, Cobo Sandra, Trouche Stéphanie G, Fontès Pascaline, Zussy Charleine, De Deurwaerdere Philippe, Salinas Sara, Mennechet Franck Jd, Dusonchet Julien, Schneider Bernard L, Saggio Isabella, Kalatzis Vasiliki, Luquin-Piudo M Rosario, Verdier Jean-Michel, Kremer Eric J

Abstract excerpt

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease among the elderly. To understand its pathogenesis and to test therapies, animal models that faithfully reproduce key pathological PD hallmarks are needed. As a prelude to developing a model of PD, we tested the tropism, efficacy, biodistribution, and transcriptional effect of canine adenovirus type 2 (CAV-2) vectors in the brain of...

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Identifiers

PMID: 30046008
DOI: 10.1172/jci.insight.98202
PMCID: PMC6124435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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