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The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies

1 Apr 2013

Abstract excerpt

This article considers the origins of DNA damage in human spermatozoa, the methods that are available to monitor this aspect of semen quality and the clinical significance of such measurements. DNA damage in spermatozoa appears to be largely oxidative in nature, inversely correlated with levels of nuclear protamination and frequently associated with the activation of a truncated apoptotic pathway. DNA base...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23548339
DOI: 10.1093/molehr/gat025

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