Article
Modification of betanodavirus virulence by substitutions in the 3' terminal region of RNA2.
The Journal of general virology - 1 Sept 2018
Souto Sandra, Olveira José G, Dopazo Carlos P, Borrego Juan J, Bandín Isabel
Abstract excerpt
Betanodaviruses have bi-segmented positive-sense RNA genomes, consisting of RNAs 1 and 2. For some members of the related genus alphanodavirus, the 3' terminal 50 nucleotides (nt) of RNA2, including a predicted stem-loop structure (3'SL), are essential for replication. We investigate the possible existence and role of a similar structure in a reassortant betanodavirus strain (RGNNV/SJNNV). In this study, we...
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