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Article

Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer.

Journal of experimental & clinical cancer research : CR - 24 Jul 2018

Sun Yan, Peng Wenfang, He Weiwei, Luo Man, Chang Guilin, Shen Jiping, Zhao Xiaoping, Hu Yu

Abstract excerpt

BACKGROUND: The KRAS mutation is the driving force of pancreatic ductal adenocarcinoma (PDAC). Downstream effectors of KRAS signal pathways are crucial to the development of PDAC. The purpose of this study was to investigate the relationship between KRAS mutation and transgelin-2. Transgelin-2 is highly expressed in PDAC tissues compared with adjacent normal tissues. The underlying mechanism for upregulating...

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Source

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Identifiers

PMID: 30041673
DOI: 10.1186/s13046-018-0818-z
PMCID: PMC6056937

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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