Article
[Mechanism of EGFR Over-expression and Mutations Leading to Biological Characteristics Changes of Human Lung Adenocarcinoma Cells through CXCR4/CXCL12 Signaling Pathway].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 20 Jul 2018
Feng Jia, Wei Xueyan, Li Chuang, Guo Mingxiong, Peng Min, Song Qibin, Han Guang
Abstract excerpt
BACKGROUND: The epidermal growth factor receptor (EFGR) mutation was closely related to the invasion and metastasis of lung adenocarcinoma and the biological axis of CXCR4/CXCL12 (chemokine receptor 4/chemokine ligand 12) played an important role in the organ-specific metastasis of the tumor. It was a question surrounding whether there is interaction between them in the process of lung adenocarcinoma metastasis....
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