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Article

Identification of MET exon14 skipping by targeted DNA- and RNA-based next-generation sequencing in pulmonary sarcomatoid carcinomas.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2018

Li Yan, Gao Lianju, Ma Di, Qiu Tian, Li Wenbin, Li Weihua, Guo Lei, Xing Puyuan, Liu Bing, Deng Lamei, Fu Jake, Li Junling, Yu Yang, Ying Jianming

Abstract excerpt

BACKGROUND: Pulmonary sarcomatoid carcinomas (PSCs) constitutes a heterogeneous group of NSCLCs, which show poor prognosis even with aggressive surgical treatment and postoperative chemotherapy. The detection MET exon14 skipping (METex14 skipping) in PSCs suggests the targeted therapeutic opportunities with MET TKIs. PATIENTS AND METHODS: We detected MET exon14 alterations using both targeted DNA- and RNA-based...

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Source

Identifiers

PMID: 30032818
DOI: 10.1016/j.lungcan.2018.06.001

Genes

MET
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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