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Article

Optimized Detection of Unknown MET Exon 14 Skipping Mutations in Routine Testing for Patients With Non-Small-Cell Lung Cancer.

JCO precision oncology - 1 Feb 2023

Sun Rui, Wang Zhizhong, Zhao Jiuzhou, Ren Pengfei, Ma Jie, Guo Yongjun

Abstract excerpt

PURPOSE: MET exon 14 (METex14) skipping is an actionable biomarker in non-small-cell lung cancer. However, MET variants are highly complex and diverse, and not all variants lead to exon 14 skipping. Assessing the skipping effect of unknown variants is still a key issue in molecular diagnosis. MATERIALS AND METHODS: We retrospectively collected MET variants around exon 14 from 4,233 patients with non-small-cell...

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PMID: 36848606
DOI: 10.1200/PO.22.00482

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