Article
Mycobacterium bovis ESAT-6, CFP-10 and EspC antigens show high conservation among field isolates.
Tuberculosis (Edinburgh, Scotland) - 1 Jul 2018
Encinas M, Marfil M J, Garbaccio S, Barandiaran S, Huertas P, Morsella C, Macías A, Magnano G, Zapata L, Bigi F, Cataldi A, Paolicchi F, Zumárraga M, Eirin M E
Abstract excerpt
ESAT-6, CFP-10 and EspC are virulence factors that have been extensively assayed for bovine and human tuberculosis diagnosis due their potent T-cell inducing activities. While polymorphisms of ESAT-6 and CFP-10 were analyzed, with the description of CFP-10 variants in M. tuberculosis, this fact has not been explored in M. bovis field isolates. The coding sequences of esxA (ESAT-6), esxB (CFP-10) and mb3645c...
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