Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia.

doi:10.1080/19336950.2018.1499368

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Article

Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia.

Channels (Austin, Tex.) - 1 Jan 2018

Zhang Qing, Chen Junjie, Qin Yao, Wang Juejin, Zhou Lei

Abstract excerpt

The voltage-gated L-type calcium channel (LTCC) is essential for multiple cellular processes. In the heart, calcium influx through LTCC plays an important role in cardiac electrical excitation. Mutations in LTCC genes, including CACNA1C, CACNA1D, CACNB2 and CACNA2D, will induce the dysfunctions of calcium channels, which result in the abnormal excitations of cardiomyocytes, and finally lead to cardiac...

Topics

Animals
Arrhythmias, Cardiac
Calcium Channels, L-Type
Humans
Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 30027834
DOI: 10.1080/19336950.2018.1499368
PMCID: PMC6104696

Genes

CACNB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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