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Article

Hypertrophic chondrocytes have a limited capacity to cope with increases in endoplasmic reticulum stress without triggering the unfolded protein response.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Oct 2012

Kung Louise H W, Rajpar M Helen, Briggs Michael D, Boot-Handford Raymond P

Abstract excerpt

Mutations causing metaphyseal chondrodysplasia type Schmid (MCDS) (e.g., Col10a1p.N617K) induce the pathology by a mechanism involving increased endoplasmic reticulum (ER) stress triggering an unfolded protein response (UPR) in hypertrophic chondrocytes (Rajpar et al. 2009). Here we correlate the...

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Identifiers

PMID: 22859705
DOI: 10.1369/0022155412458436
PMCID: PMC3524565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22859705-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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