Article
Beta-1,4-galactosyltransferase 2 c.909C>T gene variant is predictive of on-clopidogrel platelet reactivity.
Pharmacogenomics - 1 Aug 2018
Pallet Nicolas, Belleville-Rolland Tiphaine, Savalle Anne, Lejeune Manon, Mauge Laetitia, Bertil Sebastien, Loriot Marie-Anne, Gaussem Pascale
Abstract excerpt
CYP2C19 genotype influences clopidogrel response but only accounts for a small part of the variability in platelet reactivity. Recently, exome sequencing identified a variant of the gene encoding B4GALT2 as a potential candidate implicated in on-treatment platelet reactivity. Carriers of the B4GALT2 c.909C>T variant have lower platelet reactivity indicating that B4GALT2 could influence clopidogrel sensitivity and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.