Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection and Investigation of Eagle Effect Resistance to Vancomycin in Clostridium difficile With an ATP-Bioluminescence Assay

2 Jul 2018

Abstract excerpt

Vancomycin was bactericidal against Clostridium difficile at 8-fold the minimal inhibitory concentration (MIC) using a traditional minimum bactericidal concentration (MBC) assay. However, at higher concentrations up to 64  MIC, vancomycin displayed a paradoxical ‘more-drug-kills-less’ Eagle effect against C. difficile. To overcome challenges associated with performing the labor-intensive agar-based MBC method...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clostridium difficile and Clostridium perfringens research
Share to Microscopic Colitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30013531
DOI: 10.3389/fmicb.2018.01420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection and Investigation of Eagle Effect Resistance to Vancomycin in Clostridium difficile With an ATP-Bioluminescence AssayPMID 30013531Read ↗

A nanoplex PCR assay for the rapid detection of vancomycin and bifunctional aminoglycoside resistance genes in Enterococcus speciesSemantic proximity Read ↗

In vitro susceptibility of genotypically distinct and clonal Clostridium difficile strains to oritavancin.Semantic proximity Read ↗

Regulation and Anaerobic Function of the Clostridioides difficile β-LactamaseSemantic proximity Read ↗

Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571.Semantic proximity Read ↗

Amplification-Free Detection of Antibiotic Resistance in <i>Enterococcus faecium</i> using PNA-FISHSemantic proximity Read ↗

Vancomycin Tolerance in Methicillin-Resistant Staphylococcus aureus: Influence of Vancomycin, Daptomycin, and Telavancin on Differential Resistance Gene ExpressionSemantic proximity Read ↗

Increased <emph type="ital">Clostridium difficile</emph> Virulence Demands New Treatment ApproachSemantic proximity Read ↗

Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infectionsSemantic proximity Read ↗

Restoration of daptomycin sensitivity with adjunctive cefazolin is associated with C-terminal MprF mutations in MRSA bacteremia isolates.Semantic proximity Read ↗

Rapid Detection of <i>Clostridium difficile</i> in Feces by Real-Time PCRSemantic proximity Read ↗

Development of a PCR Assay for Rapid Detection of EnterococciSemantic proximity Read ↗

Comparison of agar dilution, broth microdilution, E-test, disk diffusion, and automated Vitek methods for testing susceptibilities of Enterococcus spp. to vancomycin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.