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Article

Molecular mechanism of the tree shrew's insensitivity to spiciness.

PLoS biology - 1 Jul 2018

Han Yalan, Li Bowen, Yin Ting-Ting, Xu Cheng, Ombati Rose, Luo Lei, Xia Yujie, Xu Lizhen, Zheng Jie, Zhang Yaping, Yang Fan, Wang Guo-Dong, Yang Shilong, Lai Ren

Abstract excerpt

Spicy foods elicit a pungent or hot and painful sensation that repels almost all mammals. Here, we observe that the tree shrew (Tupaia belangeri chinensis), which possesses a close relationship with primates and can directly and actively consume spicy plants. Our genomic and functional analyses reveal that a single point mutation in the tree shrew's transient receptor potential vanilloid type-1 (TRPV1) ion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30001322
DOI: 10.1371/journal.pbio.2004921
PMCID: PMC6042686

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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