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Article

Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex.

PLoS genetics - 1 Jul 2018

Leal-Esteban Lucia Carolina, Rothé Benjamin, Fortier Simon, Isenschmid Manuela, Constam Daniel B

Abstract excerpt

Altered glucose and lipid metabolism fuel cystic growth in polycystic kidneys, but the cause of these perturbations is unclear. Renal cysts also associate with mutations in Bicaudal C1 (Bicc1) or in its self-polymerizing sterile alpha motif (SAM). Here, we found that Bicc1 maintains normoglycemia and the expression of the gluconeogenic enzymes FBP1 and PEPCK in kidneys. A proteomic screen revealed that Bicc1...

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Source

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Identifiers

PMID: 29995892
DOI: 10.1371/journal.pgen.1007487
PMCID: PMC6056059

Genes

FBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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