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Article

Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals.

Cell research - 1 Nov 2014

Huang August Y, Xu Xiaojing, Ye Adam Y, Wu Qixi, Yan Linlin, Zhao Boxun, Yang Xiaoxu, He Yao, Wang Sheng, Zhang Zheng, Gu Bowen, Zhao Han-Qing, Wang Meng, Gao Hua, Gao Ge, Zhang Zhichao, Yang Xiaoling, Wu Xiru, Zhang Yuehua, Wei Liping

Abstract excerpt

Postzygotic single-nucleotide mutations (pSNMs) have been studied in cancer and a few other overgrowth human disorders at whole-genome scale and found to play critical roles. However, in clinically unremarkable individuals, pSNMs have never been identified at whole-genome scale largely due to technical difficulties and lack of matched control tissue samples, and thus the genome-wide characteristics of pSNMs...

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Identifiers

PMID: 25312340
DOI: 10.1038/cr.2014.131
PMCID: PMC4220156

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