Article
Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients.
BMC medical genetics - 4 Jul 2018
Rimpelä Jenni M, Pörsti Ilkka H, Jula Antti, Lehtimäki Terho, Niiranen Teemu J, Oikarinen Lasse, Porthan Kimmo, Tikkakoski Antti, Virolainen Juha, Kontula Kimmo K, Hiltunen Timo P
Abstract excerpt
BACKGROUND: Reduced nocturnal fall (non-dipping) of blood pressure (BP) is a predictor of cardiovascular target organ damage. No genome-wide association studies (GWAS) on BP dipping have been previously reported. METHODS: To study genetic variation affecting BP dipping, we conducted a GWAS in Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n = 204) using the mean night-to-day BP ratio...
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