Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells.

Molecular & cellular proteomics : MCP - 1 Oct 2018

Ressa Anna, Bosdriesz Evert, de Ligt Joep, Mainardi Sara, Maddalo Gianluca, Prahallad Anirudh, Jager Myrthe, de la Fonteijne Lisanne, Fitzpatrick Martin, Groten Stijn, Altelaar A F Maarten, Bernards René, Cuppen Edwin, Wessels Lodewyk, Heck Albert J R

Abstract excerpt

Intrinsic and/or acquired resistance represents one of the great challenges in targeted cancer therapy. A deeper understanding of the molecular biology of cancer has resulted in more efficient strategies, where one or multiple drugs are adopted in novel therapies to tackle resistance. This beneficial effect of using combination treatments has also been observed in colorectal cancer patients harboring the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Synergism
Share to Feedback, Physiological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockout Techniques

Share to MAP Kinase Signaling System

Share to Phosphatidylinositol 3-Kinases

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Proto-Oncogene Proteins c-akt

Share to Systems Biology

Source

Open in PubMed Open full text

Identifiers

PMID: 29970458
DOI: 10.1074/mcp.RA117.000486
PMCID: PMC6166676

Genes

BRAF
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells.PMID 29970458Read ↗

A system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cellsSemantic proximity Read ↗

Multi-omics analysis delineates resistance mechanisms associated with BRAF inhibition in melanoma cells.Semantic proximity Read ↗

Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibitionSemantic proximity Read ↗

BRAFV600E patient derived colon cancer organoids identify biomarkers of response to EGFR and BRAF inhibition and replicate clinical data.Semantic proximity Read ↗

Tumor Cell Resistance to the Inhibition of BRAF and MEK1/2Semantic proximity Read ↗

Pharmacoproteomic characterisation of human colon and rectal cancerSemantic proximity Read ↗

Tumor Cell Resistance to the Inhibition of BRAF and MEK1/2.Semantic proximity Read ↗

Cellular mechanisms of acquired drug resistance against regorafenib in colon cancer cellsSemantic proximity Read ↗

Tissue Proteomic Signatures of BRAF-Mutated Colorectal Cancer Reveal New Insights into Aggressiveness, Immune Modulation, and Metabolic Reprogramming.Semantic proximity Read ↗

Metabolic Singularities in Microsatellite-Stable Colorectal Cancer: Identifying Key Players in Immunosuppression to Improve the Immunotherapy ResponseSemantic proximity Read ↗

Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanomaSemantic proximity Read ↗

Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.