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Article

Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling.

British journal of pharmacology - 1 Sept 2018

Melancia Francesca, Schiavi Sara, Servadio Michela, Cartocci Veronica, Campolongo Patrizia, Palmery Maura, Pallottini Valentina, Trezza Viviana

Abstract excerpt

BACKGROUND AND PURPOSE: Autism spectrum disorder (ASD) is more commonly diagnosed in males than in females. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is an environmental risk factor of ASD. Male rats prenatally exposed to VPA show socio-emotional autistic-like dysfunctions that have been related to changes in the activity of the endocannabinoid anandamide. Here, we have investigated if...

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Identifiers

PMID: 29968249
DOI: 10.1111/bph.14435
PMCID: PMC6109221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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