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Article

Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2023

Schiavi Sara, Manduca Antonia, Carbone Emilia, Buzzelli Valeria, Rava Alessandro, Feo Alessandro, Ascone Fabrizio, Morena Maria, Campolongo Patrizia, Hill Matthew N, Trezza Viviana

Abstract excerpt

Autism spectrum disorder (ASD) has a multifactorial etiology. Major efforts are underway to understand the neurobiological bases of ASD and to develop efficacious treatment strategies. Recently, the use of cannabinoid compounds in children with neurodevelopmental disorders including ASD has received increasing attention. Beyond anecdotal reports of efficacy, however, there is limited current evidence supporting...

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PMID: 36114286
DOI: 10.1038/s41386-022-01454-7
PMCID: PMC10156791

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