Article
Epistatic Oncogenic Interactions Determine Cancer Susceptibility to Immunotherapy.
Cancer discovery - 1 Jul 2018
Etxeberria Iñaki, Teijeira Alvaro, Montuenga Luis M, Berraondo Pedro, Melero Ignacio
Abstract excerpt
Cancer genetic alterations and epigenetics control the malignant phenotype of tumor cells and the stroma. Synergistic oncogenic alterations may cooperatively dictate immunogenicity, level of infiltration by immune system cells, and response to immunotherapy in an epistatic fashion. The work of Skoulidis and colleagues shows that concomitant RAS and STK11/LKB1 mutations in non-small cell lung adenocarcinomas...
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