Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus

Abstract excerpt

The RNA helicase LGP2 (Laboratory of Genetics and Physiology 2) is a non-signaling member of the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), whose pivotal role on innate immune responses against RNA viruses is being increasingly uncovered.LGP2 is known to work in synergy with melanoma differentiation-associated gene 5 (MDA5) to promote the antiviral response induced by picornavirus...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Animal Disease Management and Epidemiology
• Share to interferon and immune responses
• Share to Viral Infections and Vectors