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Article

Analysis of Porcine RIG-I Like Receptors Revealed the Positive Regulation of RIG-I and MDA5 by LGP2.

Frontiers in immunology - 1 Jan 2021

Li Shuangjie, Yang Jie, Zhu Yuanyuan, Wang Hui, Ji Xingyu, Luo Jia, Shao Qi, Xu Yulin, Liu Xueliang, Zheng Wanglong, Meurens François, Chen Nanhua, Zhu Jianzhong

Abstract excerpt

The RLRs play critical roles in sensing and fighting viral infections especially RNA virus infections. Despite the extensive studies on RLRs in humans and mice, there is a lack of systemic investigation of livestock animal RLRs. In this study, we characterized the porcine RLR members RIG-I, MDA5 and LGP2. Compared with their human counterparts, porcine RIG-I and MDA5 exhibited similar signaling activity to...

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Identifiers

PMID: 34093517
DOI: 10.3389/fimmu.2021.609543
PMCID: PMC8169967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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