Identification of an enhancer region within the TP63/LEPREL1 locus containing genetic variants associated with bladder cancer risk.

doi:10.1007/s13402-018-0393-5

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Article

Identification of an enhancer region within the TP63/LEPREL1 locus containing genetic variants associated with bladder cancer risk.

Cellular oncology (Dordrecht, Netherlands) - 1 Oct 2018

Dudek Aleksandra M, Vermeulen Sita H, Kolev Dimitar, Grotenhuis Anne J, Kiemeney Lambertus A L M, Verhaegh Gerald W

Abstract excerpt

PURPOSE: Genome-wide association studies (GWAS) have led to the identification of a bladder cancer susceptibility variant (rs710521) in a non-coding intergenic region between the TP63 and LEPREL1 genes on chromosome 3q28, suggesting a role in the transcriptional regulation of these genes. In this study, we aimed to functionally characterize the 3q28 bladder cancer risk locus. METHODS: Fine-mapping was performed...

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PMID: 29956121
DOI: 10.1007/s13402-018-0393-5
PMCID: PMC6153957

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TP63

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