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Article

Genetic and neuroattenuation phenotypic characteristics and their stabilities of SA14-14-2 vaccine seed virus.

Vaccine - 25 Jul 2018

Liu Xinyu, Zhao Danhua, Jia Lili, Xu Hongshan, Na Rui, Ge Yonghong, Liu Shaoxiang, Yu Yongxin, Li Yuhua

Abstract excerpt

Japanese encephalitis (JE) live attenuated vaccine SA14-14-2 is the most widely used JE vaccine in the world. Large-scale clinical trials have demonstrated satisfactory safety and efficacy profiles. The establishment of genetic and attenuated neurovirulence characteristics and their stabilities of SA14-14-2 virus are important in relation to vaccine safety in humans. Therefore, several researchers have studied...

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Identifiers

PMID: 29954631
DOI: 10.1016/j.vaccine.2018.06.040

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