Article
miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models.
Nature communications - 26 Jun 2018
Cerro-Herreros Estefania, Sabater-Arcis Maria, Fernandez-Costa Juan M, Moreno Nerea, Perez-Alonso Manuel, Llamusi Beatriz, Artero Ruben
Abstract excerpt
Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cells. We thus identify miR-23b and miR-218, and confirm that they downregulate MBNL proteins in this...
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