Article
HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer.
The Journal of clinical investigation - 1 Aug 2018
Alyamani Mohammad, Emamekhoo Hamid, Park Sunho, Taylor Jennifer, Almassi Nima, Upadhyay Sunil, Tyler Allison, Berk Michael P, Hu Bo, Hwang Tae Hyun, Figg William Douglas, Peer Cody J, Chien Caly, Koshkin Vadim S, Mendiratta Prateek, Grivas Petros, Rini Brian, Garcia Jorge, Auchus Richard J, Sharifi Nima
Abstract excerpt
BACKGROUND: A common germline variant in HSD3B1(1245A>C) encodes for a hyperactive 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) missense that increases metabolic flux from extragonadal precursor steroids to DHT synthesis in prostate cancer. Enabling of extragonadal DHT synthesis by HSD3B1(1245C) predicts for more rapid clinical resistance to castration and sensitivity to extragonadal androgen synthesis inhibition....
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