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The oncogenic potential of BK ‐polyomavirus is linked to viral integration into the human genome

14 Jul 2015

Abstract excerpt

It has been suggested that BK-polyomavirus is linked to oncogenesis via high expression levels of large T-antigen in some urothelial neoplasms arising following kidney transplantation. However, a causal association between BK-polyomavirus, large T-antigen expression and oncogenesis has never been demonstrated in humans. Here we describe an investigation using high-throughput sequencing of tumour DNA obtained from...

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PMID: 26172456
DOI: 10.1002/path.4584

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