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Article

Interpreting secondary cardiac disease variants in an exome cohort.

Circulation. Cardiovascular genetics - 1 Aug 2013

Ng David, Johnston Jennifer J, Teer Jamie K, Singh Larry N, Peller Lindsey C, Wynter Jamila S, Lewis Katie L, Cooper David N, Stenson Peter D, Mullikin James C, Biesecker Leslie G

Abstract excerpt

BACKGROUND: Massively parallel sequencing to identify rare variants is widely practiced in medical research and in the clinic. Genome and exome sequencing can identify the genetic cause of a disease (primary results), but it can also identify pathogenic variants underlying diseases that are not being sought (secondary or incidental results). A major controversy has developed surrounding the return of secondary...

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Identifiers

PMID: 23861362
DOI: 10.1161/CIRCGENETICS.113.000039
PMCID: PMC3887521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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