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In Vitro Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different β-Lactam Resistance Phenotypes.

Antimicrobial agents and chemotherapy - 1 Sept 2018

Robin Frédéric, Auzou Michel, Bonnet Richard, Lebreuilly Romain, Isnard Christophe, Cattoir Vincent, Guérin François

Abstract excerpt

The study evaluated the in vitro activity of ceftolozane-tazobactam (C/T) against 94 unique clinical isolates of Enterobacter cloacae complex (ECC). No difference was observed according to the ECC cluster. The in vitro activity greatly varied depending on the β-lactamase-producing profile: 100%, 67%, and 19% of wild-type, extended-spectrum β-lactamase (ESBL)-producing, and AmpC-overproducing strains,...

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Identifiers

PMID: 29914962
DOI: 10.1128/AAC.00675-18
PMCID: PMC6125531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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