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Article

Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL-NKG2D Axis.

Frontiers in immunology - 1 Jan 2018

Wang Zhan, Wang Zenan, Li Shu, Li Binghao, Sun Lingling, Li Hengyuan, Lin Peng, Wang Shengdong, Teng Wangsiyuan, Zhou Xingzhi, Ye Zhaoming

Abstract excerpt

γδ T cell-based immunotherapy for osteosarcoma (OS) has shown limited success thus far. DNA-demethylating agents not only induce tumor cell death but also have an immunomodulatory function. In this study, we have assessed the potential benefit of combining decitabine (DAC, a DNA demethylation drug) and γδ T cells for OS immunotherapy. DAC increased the expression of natural killer group 2D (NKG2D) ligands...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29910819
DOI: 10.3389/fimmu.2018.01239
PMCID: PMC5992281

Genes

MICB
ULBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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