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Article

TLS dependent and independent functions of DNA polymerase eta (Polη/Rad30) from Pathogenic Yeast <i>Candida albicans</i>

16 Jun 2018

Abstract excerpt

Polη, a unique TLS DNA polymerase that promotes efficient bypass of UV-induced CPDs and cisplatin adducts, has not been explored in Candida species yet. Here, we show that CaPolη plays a vital role in protecting Candida albicans genome from diverse array of DNA damaging agents, not limited to UV and cisplatin. Polη deficient strain did not exhibit any hyphal development in the presence of UV and cisplatin while...

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PMID: 29907984
DOI: 10.1111/mmi.14004

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