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Article

Characterization of NS5A and NS5B Resistance-Associated Substitutions from Genotype 1 Hepatitis C Virus Infected Patients in a Portuguese Cohort.

Viruses - 26 Apr 2018

Brandão Ruben, Marcelino Rute, Gonçalves Fátima, Diogo Isabel, Carvalho Ana, Cabanas Joaquim, Costa Inês, Brogueira Pedro, Ventura Fernando, Miranda Ana, Mansinho Kamal, Gomes Perpétua

Abstract excerpt

This study is focused on the prevalent NS5 coding region resistance-associated substitutions (RASs) in DAA-naive genotype (GT)1 HCV-infected patients and their potential impact on success rates. Plasma RNA from 81 GT1 HCV-infected patients was extracted prior to an in-house nested RT-PCR of the NS5 coding region, which is followed by Sanger population sequencing. NS5A RASs were present in 28.4% (23/81) of all...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29701642
DOI: 10.3390/v10050223
PMCID: PMC5977216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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