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Article

Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

AIDS (London, England) - 24 Sept 2014

Neogi Ujjwal, Rao Shwetha D, Bontell Irene, Verheyen Jens, Rao Vasudev R, Gore Sagar C, Soni Neelesh, Shet Anita, Schülter Eugen, Ekstrand Maria L, Wondwossen Amogne, Kaiser Rolf, Madhusudhan Mallur S, Prasad Vinayaka R, Sonnerborg Anders

Abstract excerpt

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated...

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Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25102091
DOI: 10.1097/QAD.0000000000000419
PMCID: PMC4198440

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