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Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk

1 Jun 2018

Abstract excerpt

Confirmed reports of Zika virus (ZIKV) in seminal fluid months after clearance of viremia suggests that ZIKV can establish persistent infection in the seminiferous tubules, an immune privileged site of the testis. The seminiferous tubule epithelium is mainly composed of Sertoli cells that function to nourish and protect developing germ cells. We recently demonstrated that primary human Sertoli cells (hSeC) were...

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PMID: 29880853
DOI: 10.1038/s41598-018-27027-7

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