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Zika Virus Infects Human Sertoli Cells and Modulates the Integrity of the <i>In Vitro</i> Blood-Testis Barrier Model

7 Sept 2017

Abstract excerpt

ABSTRACT Confirmed reports of Zika virus (ZIKV) in human seminal fluid for months after the clearance of viremia suggest the ability of ZIKV to establish persistent infection in the seminiferous tubules, an immune-privileged site in the testis protected by the blood-testis barrier, also called the Sertoli cell (SC) barrier (SCB). However, cellular targets of ZIKV in human testis and mechanisms by which the virus...

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Identifiers

PMID: 28878076
DOI: 10.1128/jvi.00623-17

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