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Article

Long-chain polyunsaturated fatty acids, gestation duration, and birth size: a Mendelian randomization study using fatty acid desaturase variants.

The American journal of clinical nutrition - 1 Jul 2018

Bernard Jonathan Y, Pan Hong, Aris Izzuddin M, Moreno-Betancur Margarita, Soh Shu-E, Yap Fabian, Tan Kok Hian, Shek Lynette P, Chong Yap-Seng, Gluckman Peter D, Calder Philip C, Godfrey Keith M, Chong Mary Foong-Fong, Kramer Michael S, Karnani Neerja, Lee Yung Seng

Abstract excerpt

Background: In randomized trials, supplementation of n-3 (ω-3) long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy has resulted in increased size at birth, which is attributable to longer gestation. Objective: We examined this finding by using a Mendelian randomization approach utilizing fatty acid desaturase (FADS) gene variants affecting LC-PUFA metabolism. Design: As part of a tri-ethnic...

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Identifiers

PMID: 29878044
DOI: 10.1093/ajcn/nqy079
PMCID: PMC6038907

Genes

FADS1
FADS2
FADS3

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