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Article

Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3

5 Jun 2018

Abstract excerpt

Cancer cells typically shift their metabolism to aerobic glycolysis to fulfill the demand of energy and macromolecules to support their proliferation. Glucose transporter (GLUT) family-mediated glucose transport is the pacesetter of aerobic glycolysis and, thus, is critical for tumor cell metabolism. Yin Yang 1 (YY1) is an oncogene crucial for tumorigenesis; however, its role in tumor cell glucose metabolism...

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PMID: 29869834
DOI: 10.1111/cas.13662

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