Article
Allelism in the HLA class I multigene family.
Annales de l'Institut Pasteur. Immunologie - 1 Jan 2000
Sodoyer R, Nguyen C, Strachan T, Santoni M J, Damotte M, Trucy J, Jordan B R
Abstract excerpt
Recent data on the structure of functional HLA class I genes shows that, at least at the HLA-A locus, the allelic genes are more related to each other than to HLA genes from other loci. This "A-ness" is discernible at the protein sequence level but much more evident when nucleotide sequences are compared; the homology is particularly striking in the 3' non-coding region. Genes coding for the same HLA specificity...
Topics
- Alleles
- Animals
- Base Sequence
- Chromosome Mapping
- DNA
- DNA Restriction Enzymes
- HLA Antigens
- HLA-A Antigens
- Humans
- Mice