Improvement in Overall Survival in a Randomized Study That Compared Dacomitinib With Gefitinib in Patients With Advanced Non-Small-Cell Lung Cancer and EGFR-Activating Mutations.

doi:10.1200/JCO.2018.78.7994

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Article

Improvement in Overall Survival in a Randomized Study That Compared Dacomitinib With Gefitinib in Patients With Advanced Non-Small-Cell Lung Cancer and EGFR-Activating Mutations.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Aug 2018

Mok Tony S, Cheng Ying, Zhou Xiangdong, Lee Ki Hyeong, Nakagawa Kazuhiko, Niho Seiji, Lee Min, Linke Rolf, Rosell Rafael, Corral Jesus, Migliorino Maria Rita, Pluzanski Adam, Sbar Eric I, Wang Tao, White Jane Liang, Wu Yi-Long

Abstract excerpt

Purpose ARCHER 1050, a randomized, open-label, phase III study of dacomitinib versus gefitinib in treatment-naïve patients with advanced non-small-cell lung cancer (NSCLC) and activating mutations in EGFR, reported significant improvement in progression-free survival with dacomitinib. The mature overall survival (OS) analysis for the intention-to-treat population is presented here. Patients and Methods In this...

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PMID: 29864379
DOI: 10.1200/JCO.2018.78.7994

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EGFR

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