Updated Overall Survival in a Randomized Study Comparing Dacomitinib with Gefitinib as First-Line Treatment in Patients with Advanced Non-Small-Cell Lung Cancer and EGFR-Activating Mutations.

doi:10.1007/s40265-020-01441-6

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Updated Overall Survival in a Randomized Study Comparing Dacomitinib with Gefitinib as First-Line Treatment in Patients with Advanced Non-Small-Cell Lung Cancer and EGFR-Activating Mutations.

Drugs - 1 Feb 2021

Mok Tony S, Cheng Ying, Zhou Xiangdong, Lee Ki Hyeong, Nakagawa Kazuhiko, Niho Seiji, Chawla Alka, Rosell Rafael, Corral Jesus, Migliorino Maria Rita, Pluzanski Adam, Noonan Kay, Tang Yiyun, Pastel Malaika, Wilner Keith D, Wu Yi-Long

Abstract excerpt

BACKGROUND: ARCHER 1050, an ongoing, randomized, open-label, phase III trial of dacomitinib versus gefitinib in newly diagnosed patients with advanced non-small-cell lung cancer (NSCLC) and an EGFR-activating mutation, reported significant improvement in overall survival (OS) with dacomitinib. OBJECTIVE: This paper reports an updated OS analysis of ARCHER 1050 after an extended follow-up. PATIENTS AND METHODS: In...

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PMID: 33331989
DOI: 10.1007/s40265-020-01441-6
PMCID: PMC7932969

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