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Article

Functional cooperation between HIF-1α and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2018

Meng Shuyan, Wang Guorui, Lu Yang, Fan Zhen

Abstract excerpt

OBJECTIVE: Hypoxia-inducible factor 1 (HIF-1) and activator protein 1 (AP-1) are important transcription factors regulating expression of genes involved in cell survival. HIF-1α and c-Jun are key components of HIF-1 and AP-1, respectively, and are regulated by epidermal growth factor receptor (EGFR)-mediated cell signaling and tumor microenvironmental cues. The roles of HIF-1α and c-Jun in development of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29858032
DOI: 10.1016/j.lungcan.2018.04.024
PMCID: PMC6004101

Genes

EGFR

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