Article
The search for modifier genes in Huntington disease - Multifactorial aspects of a monogenic disorder.
Molecular and cellular probes - 1 Dec 2016
Arning Larissa
Abstract excerpt
It is becoming increasingly evident that the underlying mutation of a single locus is often insufficient for the prediction of the comprehensive phenotype in human Mendelian disorders, implicating that there is no clear distinction between monogenic and complex traits. By definition, monogenic traits show a classic pattern of inheritance and are strongly influenced by variation within a single gene. However, many...
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