Article
Whole-exome sequencing of duodenal neuroendocrine tumors in patients with neurofibromatosis type 1.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2018
Noë Michaël, Pea Antonio, Luchini Claudio, Felsenstein Matthäus, Barbi Stefano, Bhaijee Feriyl, Yonescu Raluca, Ning Yi, Adsay N Volkan, Zamboni Giuseppe, Lawlor Rita T, Scarpa Aldo, Offerhaus G Johan A, Brosens Lodewijk A A, Hruban Ralph H, Roberts Nicholas J, Wood Laura D
Abstract excerpt
Neurofibromatosis type 1 (NF1) is a hereditary cancer predisposition syndrome characterized by frequent cutaneous and nervous system abnormalities. Patients with NF1 also have an increased prevalence of multiple gastrointestinal and peripancreatic neoplasms-neuroendocrine tumors of the ampulla that express somatostatin are particularly characteristic of NF1. In this study, we characterize the genetic alterations...
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