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C/EBPβ isoform-specific regulation of migration and invasion in triple-negative breast cancer cells

18 Jan 2022

Abstract excerpt

The transcription factor C/EBPβ is a master regulator of mammary gland development and tissue remodelling during lactation. The CEBPB-mRNA is translated into three distinct protein isoforms named C/EBPβ-LAP1, -LAP2 and -LIP that are functionally different. The smaller isoform LIP lacks the N-terminal transactivation domains and is considered to act as an inhibitor of the transactivating LAP1/2 isoforms by...

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PMID: 35042889
DOI: 10.1038/s41523-021-00372-z

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