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Article

Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation.

Scientific reports - 29 May 2018

Weng Tzu-Yang, Wu Hsuan Franziska, Li Chung-Yen, Hung Yu-Hsuan, Chang Yu-Wei, Chen Yi-Ling, Hsu Hui-Ping, Chen Yu-Hung, Wang Chih-Yang, Chang Jang-Yang, Lai Ming-Derg

Abstract excerpt

Homoharringtonine (HHT), an inhibitor of protein synthesis, has been used to treat leukemia. Its therapeutic effects on non-small cell lung adenocarcinoma carrying KRAS mutation and their immune system are less understood. The present study examined the therapeutic efficacy and the immune effects of HHT in two murine lung tumor models, xenograft and transgenic, carrying the Kras mutation G12D and G12C...

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29844447
DOI: 10.1038/s41598-018-26454-w
PMCID: PMC5974086

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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