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Article

Polyphyllin I Overcomes EMT-Associated Resistance to Erlotinib in Lung Cancer Cells via IL-6/STAT3 Pathway Inhibition.

Biological & pharmaceutical bulletin - 1 Aug 2017

Lou Wei, Chen Yan, Zhu Ke-Ying, Deng Huizi, Wu Tianhao, Wang Jun

Abstract excerpt

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is the most important limiting factor for treatment efficiency in EGFR-mutant non-small cell lung cancer (NSCLC). Much work has linked the epithelial-mesenchymal transition (EMT) to the emergence of drug resistance, consequently, ongoing research has been focused on exploring the therapeutic options to reverse EMT for...

Topics

Adenocarcinoma
Adenocarcinoma of Lung
Animals
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Diosgenin
Drug Resistance, Neoplasm
Drug Synergism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epithelial-Mesenchymal Transition

ErbB Receptors

Erlotinib Hydrochloride

Humans

Interleukin-6

Lung Neoplasms

Melanthiaceae

Mice

Source

Identifiers

PMID: 28515374
DOI: 10.1248/bpb.b17-00271

Genes

EGFR
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Polyphyllin I Overcomes EMT-Associated Resistance to Erlotinib in Lung Cancer Cells via IL-6/STAT3 Pathway Inhibition.PMID 28515374Read ↗

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