A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin

Abstract excerpt

Treatment change following a genetic diagnosis of MODY is frequently indicated, but little is known about the factors predicting future treatment success. We therefore conducted the first prospective study to determine the impact of a genetic diagnosis on individuals with GCK -, HNF1A - or HNF4A -MODY in the UK, and to identify clinical characteristics predicting treatment success (i.e. HbA 1c ≤58 mmol/mol...

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