Article
Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/Lcn2/Twist1 pathway.
Hepatology (Baltimore, Md.) - 1 Oct 2013
Wang Yun-Peng, Yu Goung-Ran, Lee Mi-Jin, Lee Sang-Yeop, Chu In-Sun, Leem Sun-Hee, Kim Dae-Ghon
Abstract excerpt
UNLABELLED: Lipocalin-2 (Lcn2) is preferentially expressed in hepatocellular carcinoma (HCC). However, the functional role of Lcn2 in HCC progression is still poorly understood, particularly with respect to its involvement in invasion and metastasis. The purpose of this study was to investigate whether Lcn2 is associated with the epithelial-mesenchymal transition (EMT) in HCC and to elucidate the underlying...
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